ZOFRAN ODT Reviews (ONDANSETRON)

Average Rating: 3.7 (74 Ratings)

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 GASTROINTESTINAL, MISCELLANEOUS

 Type: Rx Drug

  

ZOFRAN ODT  (ONDANSETRON):  This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. Ondansetron works by blocking one of the body's natural substances (serotonin) that causes vomiting.   FDA Approval Date: 1999-01-27 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ZOFRAN ODT: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ZOFRAN ODTCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  "morning" sickness severe insomnia Note on the dosage: the prescription was to take a 4mg tablet every 8 hours or as needed. I generally only took it once per day, occasionally twice, and once or twice I took it three times in a day. It worked wonderfully for my severe morning sickness- I felt 100% better! Unfortunately, I finally figured out that it was the cause of SEVERE INSOMNIA for me. I was getting 0-2 hours of sleep per night. Doc gave me Ambien and I STILL didn't sleep. I did some research and found it is selective antagonist of the serotonin receptor subtype, 5-HT3, and decided to see what would happen if I stopped taking it. The first 3 days off Zofran nothing happened. After that, each day I slept about 1 hour more, but I was more and more ill. At the 6 day mark, I was severely ill all over again. I switched to phenergan and hope it will be good enough that I am not throwing up and that it does not cause the severe insomnia. I have seen no other reports of such insomnia caused by Zofran, and expect I am an unfortunate and unique case. F 31 42 days
4mg 3X day
11/1/2010
 1  nausea from pain med takocardia and siezure...went to er due to pain from kidney infection...not on any other meds...nausea from pain med administered..given injection of zolfran, almost immediate twitching, burning in head, seizures and takocardia...ended up admitted in telemetry for almost a week!Told seizure is a possible side effect F 22 1 days
injection 1X day
10/2/2010
 4  Extreme Nausea Headache, Constipation, Anxiety, I also felt tired and weak, but I am not sure if it is the medicaion or the virus that I have. It works GREAt to relieve upset stomache and nausea, but I had a few side effects. F 47 1 weeks
4 MG 1X day
7/11/2010
 5  severe morning sickness all day occasional headaches This is a miracle pill! For the first 2 weeks of my pregnancy i could not move from the bed with the trash can beside it. I had tried phennergan but that didn't touch the nausea. My OB prescribed me Zofran ODT and after getting it in my system for about 2 days I could work and eat just as normal as before the pregnancy. I am now 8 months pregnant and if I skip the dosing for one day I am back to the same way i was before I started. I would definately reccomend this to anyone with severe nausea. F 21 6 months
4mg 2X day
5/2/2010
 4  hyperemesis Headache, constipation This is my third pregnancy to require Zofran. The first two times it was like a miracle cure with a minor side effect of headaches. This time I am on the generic. I don't know if if it has to do with anything, but this time it it working as well. I still throw up sometimes and feel nauseous all day and the headaches are severe. F 29 5 months
4mg 2X day
4/22/2010
 3  severe all day "morning" sickness drowsiness...but could be from pregnancy as well. During my first two pregnancies, I had very severe morning sickness. I was in the hospital multiple times for it. Zofran worked, but my doctor's had to make sure I actually did need it before prescribing it. With my 3rd pregnancy, it does not seem to be working at all. I would love to know, if my body may have become immune to it. F 25 9 months
8 mg 2X day
4/9/2010
 2  hyperemesis headache, constipation this doesn't seem to be working at all. maybe it helped the first two days but now, nothing. F 29 3 weeks
4-8mg 4X day
3/20/2010
 3  Extreme Morning Sickness Headache, constipation, nausea I had extreme nausea and vomiting due to pregnancy. While my symptoms did not go completely away I was able to function and go to work. I still felt nauseous and like I was going to vomit, but never did. Took in 8 hr increments. I would take benadryl before bed and then set my alarm at 4 AM for a 5:30 wake-up and I would not throw up in the morning. It is better than nothing, but did not completely help me. F 33 2 weeks
1/18/2010
 4  Severe pregnancy all day sickness none i was prescribed 4mg tablts 2xday. During a working day, I took two, when I was home I took one. Zofran is a very pricey pill, but it worked. Some days, after taking it I didn't feel pregnant at all, others I felt nauseous a little bit. I was very skeptical about taking meds during pregnancy, but I got pregnant three months after having my first baby (didn't even get a chance to start Birth Control), and after vommiting violantly for entire 9 months (including during labor), my body was so exhausted, with being sick without a break, I decided to try it. F 22 20 days
8/15/2009
 5  morning sickness Occational headaches I was tentative about taking medication during my pregnancy, but at 9 weeks nausea was preventing me from even leaving my bed. I started by taking the prescribed dosage and felt 100% better! After a few days, I cut the pill in half to see if that would do the trick. I now take half a pill every morning and that seems to hold off nausea for the entire day. F 31 2 weeks
7/8/2009
 5  Severe Morning Sickness all day. some constipation in the beginning but this cleared up once my body adjusted. Some headaches which also cleared up. I call this drug my little miracle. My mom and sister were both sick all 9 months with their children and I am following in their footsteps so this has been very helpful. I was only having about 3 productive hours during my work day and I have a very detail-oriented job. Zofran helps me be able to work a full day and feel normal again. What a relief. Thanks to all who reccomended it. F 34 3 weeks
4/13/2009
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 5  Hyperemesis Gravidarum moderate constipation, headache I took this medication for Hyperemesis Gravidarum. I took it in ODT form and via IV. Both forms worked very well. I need to mention that it did not completely relieve the nausea, but it did control the vomiting. I would highly recommend this medication for anyone suffering from severe nausea +/- vomiting. F 34 8 months
3/4/2009
 4  pregnancy none. I found myself "sick" with pregnancy. I was 3 months along, dropped from 120 lbs. to about 105 lbs. and keeping down about three meals a week. That's when my Dr. told me to try ZOFRAN. I took ZOFRAN every day after that...through four pregnancies. With every baby I noticed that the ZOFRAN didn't help as much. Finally with my last child, at only two and a half months along, I was in the hospital fully dosed on ZOFRAN and a couple of other similar drugs... still throwing up every hour. After a week in the hospital, my Dr. (had been frantically searching for "something" to help) rushed in and with the help of a nurse, gave me a dose of steroids. Yes, steroids. It isn't something to take lightly and it was quite literally a LAST resort. HOWEVER! It WORKED! I stepped down off the ZOFRAN pump and managed with one ZOFRAN pill in the morning and a tiny bit of a steroid pill did the trick. I was careful to take just as much as I needed to feel "ok" not "great& F 30 33 months
1/9/2009
 4  Morning Sickness Fatigue It helped curb the violent episodes of throwing up. I had severe morning sickness and this medicine made it possible to finally eat, but I still had the urge to throw up, but thankfully I didn't anymore. F 27
9/26/2008
 1  Severe morning sickness no side effects I suppose I'm one of the only women out there where this drug didn't TOUCH my morning sickness. Not a bit. Might as well have been taking a placebo pill. Tried for about a week with no avail - I was SO disapointed! F 33 7 days
5/23/2008
 5  Surgery and with Flagyl None. This drug has been a lifesaver for me. I wish they had it when I had morning sickness years ago. I use it for any surgery and when taking antibiotics that make you nauseas. If you are sensitive to pain meds, take this with it and it helps. F 50 5 days
4/4/2008
 4  Nausea Non Ulcer Dyspepsia None Very satisified 7 days
1/3/2008
 5  Hyperemesis Gravidarum Severe constipation, headaches, fatigue Very expensive drug; insurance companies would rather pay for hospital stay than 9 1/2 months of this medication; best drug (IMO) for pregnant women suffering from Hyperemesis Gravidarum F 33 9 months
12/23/2007
 5  Brain Aneurysm burst Slight increase in headache on occasion. Other than that experienced no side effects. This is the best anti-nausea medication on the market today! Due to my aneurysm all I have to do is turn my head, stand up, smell food or anything and I get extremely ill. If I vomit I end up in the hospital. I now take Zofran ODT for the nausea; within a couple minutes it is gone. No more hospitalization. Unfortunately my health care provider is no longer going to carry the ODT and I will have to use the swallow. Now I will have to wait for it to work like the Phenergan which does not, compazine which does not. This is a great medication. F 44 16 months
12/2/2007
 1  Gastroparesis Nervousness, Panic attacks Too pricey and did not help F 42 1 months
11/27/2007

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